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| # | Issuer | Value | Shares | % Portfolio |
|---|---|---|---|---|
| 1 | PRAXIS PRECISION MEDICINES I | $656.0M | 2035986 | 12.83% |
| 2 | CELCUITY INC | $356.9M | 3127200 | 6.98% |
| 3 | ASCENDIS PHARMA A/S | $350.3M | 1531421 | 6.85% |
| 4 | ROIVANT SCIENCES LTD | $229.5M | 8285461 | 4.49% |
| 5 | CENTESSA PHARMACEUTICALS PLC | $208.9M | 5258903 | 4.09% |
| 6 | RHYTHM PHARMACEUTICALS INC | $206.4M | 2373795 | 4.04% |
| 7 | SPYRE THERAPEUTICS INC | $190.8M | 3783225 | 3.73% |
| 8 | NUVALENT INC | $161.9M | 1580505 | 3.17% |
| 9 | EDGEWISE THERAPEUTICS INC | $139.4M | 4423974 | 2.73% |
| 10 | PROTAGONIST THERAPEUTICS INC | $129.7M | 1230879 | 2.54% |
| 11 | APOGEE THERAPEUTICS INC | $129.7M | 1540384 | 2.54% |
| 12 | TRAVERE THERAPEUTICS INC | $123.1M | 4142551 | 2.41% |
| 13 | AMYLYX PHARMACEUTICALS INC | $115.2M | 8284882 | 2.25% |
| 14 | IMMATICS N.V | $102.2M | 10383456 | 2.00% |
| 15 | RELAY THERAPEUTICS INC | $97.0M | 9751141 | 1.90% |
| 16 | INHIBRX BIOSCIENCES INC | $97.0M | 1442707 | 1.90% |
| 17 | MEIRAGTX HLDGS PLC | $89.3M | 10326103 | 1.75% |
| 18 | ZYMEWORKS INC | $87.9M | 3510078 | 1.72% |
| 19 | SOLID BIOSCIENCES INC | $85.7M | 11906646 | 1.68% |
| 20 | DYNE THERAPEUTICS INC | $84.6M | 4668839 | 1.66% |
| 21 | BIOCRYST PHARMACEUTICALS INC | $70.8M | 7434033 | 1.38% |
| 22 | ORUKA THERAPEUTICS INC | $68.4M | 1395501 | 1.34% |
| 23 | ARTIVION INC | $60.0M | 1637290 | 1.17% |
| 24 | NURIX THERAPEUTICS INC | $57.5M | 3710877 | 1.13% |
| 25 | MODERNA INCPUT | $50.8M | 1000000 | 0.99% |
| 26 | NAUTILUS BIOTECHNOLOGY INC | $48.9M | 12594211 | 0.96% |
| 27 | CYTOMX THERAPEUTICS INC. | $47.5M | 10098824 | 0.93% |
| 28 | ALTO NEUROSCIENCE INC | $45.2M | 2009893 | 0.88% |
| 29 | ENGENE HOLDINGS INC | $39.7M | 5827506 | 0.78% |
| 30 | IMMUNOVANT INC | $39.7M | 1597383 | 0.78% |
| 31 | INTUITIVE SURGICAL INC | $39.4M | 85419 | 0.77% |
| 32 | IONIS PHARMACEUTICALS INC | $37.8M | 504000 | 0.74% |
| 33 | DAY ONE BIOPHARMACEUTICALS I | $37.6M | 1755799 | 0.74% |
| 34 | ABIVAX SA | $36.6M | 328884 | 0.72% |
| 35 | CORVUS PHARMACEUTICALS INC | $33.5M | 2292441 | 0.66% |
| 36 | REPLIGEN CORP | $33.1M | 280541 | 0.65% |
| 37 | JAZZ PHARMACEUTICALS PLC | $32.1M | 170000 | 0.63% |
| 38 | DAMORA THERAPEUTICS INC | $31.7M | 1223000 | 0.62% |
| 39 | X4 PHARMACEUTICALS INC | $27.8M | 6737648 | 0.54% |
| 40 | GUARDANT HEALTH INC | $27.7M | 300000 | 0.54% |
| 41 | BRIGHT MINDS BIOSCIENCES INC | $27.5M | 377544 | 0.54% |
| 42 | INVIVYD INC | $27.1M | 20859303 | 0.53% |
| 43 | SIONNA THERAPEUTICS INC | $26.4M | 658439 | 0.52% |
| 44 | AXSOME THERAPEUTICS INC. | $25.3M | 149950 | 0.50% |
| 45 | REVOLUTION MEDICINES INC | $25.1M | 258600 | 0.49% |
| 46 | SAB BIOTHERAPEUTICS INC | $24.6M | 6431743 | 0.48% |
| 47 | BELITE BIO INC | $24.2M | 151979 | 0.47% |
| 48 | TENAX THERAPEUTICS INC | $23.1M | 1447782 | 0.45% |
| 49 | AXOGEN INC | $23.1M | 697312 | 0.45% |
| 50 | VIRIDIAN THERAPEUTICS INC | $22.9M | 1170829 | 0.45% |
Values in USD (reported in $thousands on 13F). Source: SEC EDGAR.