RA CAPITAL MANAGEMENT, L.P.

Est. AUM

$9.44B

13F long equity, this entity only

Positions

Period

Mar 2026 (Q1)

SEC EDGAR

View filings ↗

Mar 2026 (Q1)

#	Issuer	Class	Value	Shares	% Portfolio	Discretion
1	ASCENDIS PHARMA A/S - ADR	SPONSORED ADR	$2.35B	10281496	24.92%	SOLE
2	VAXCYTE INC	COMMON STOCK	$666.8M	11474599	7.07%	SOLE
3	RHYTHM PHARMACEUTICALS INC	COMMON STOCK	$579.8M	6666837	6.14%	SOLE
4	TYRA BIOSCIENCES INC	COMMON STOCK	$467.2M	12198625	4.95%	SOLE
5	SIONNA THERAPEUTICS INC	COMMON STOCK	$397.1M	9905045	4.21%	SOLE
6	EDGEWISE THERAPEUTICS INC	COMMON STOCK	$328.5M	10428437	3.48%	SOLE
7	NEWAMSTERDAM PHARMA CO NV	COMMON STOCK	$305.7M	9550191	3.24%	SOLE
8	NUVALENT INC-A	COMMON STOCK	$259.6M	2534145	2.75%	SOLE
9	DIANTHUS THERAPEUTICS INC	COMMON STOCK	$219.2M	2611733	2.32%	SOLE
10	MINERALYS THERAPEUTICS INC	COMMON STOCK	$208.4M	7692750	2.21%	SOLE
11	SPYGLASS PHARMA INC	COMMON STOCK	$207.8M	8021117	2.20%	SOLE
12	WAVE LIFE SCIENCES LTD	COMMON STOCK	$195.6M	26975505	2.07%	SOLE
13	SEPTERNA INC	COMMON STOCK	$168.1M	6995858	1.78%	SOLE
14	DISC MEDICINE INC	COMMON STOCK	$156.7M	2450221	1.66%	SOLE
15	JANUX THERAPEUTICS INC	COMMON STOCK	$155.5M	11189693	1.65%	SOLE
16	BIOCRYST PHARMACEUTICALS INC	COMMON STOCK	$150.7M	15827186	1.60%	SOLE
17	BICARA THERAPEUTICS INC	COMMON STOCK	$144.3M	7255993	1.53%	SOLE
18	PRAXIS PRECISION MEDICINES I	COMMON STOCK	$120.4M	373787	1.28%	SOLE
19	GH RESEARCH PLC	COMMON STOCK	$107.9M	7676697	1.14%	SOLE
20	ZAI LAB LTD-ADR	COMMON STOCK	$107.4M	5707262	1.14%	SOLE
21	TAYSHA GENE THERAPIES INC	COMMON STOCK	$105.3M	23555648	1.12%	SOLE
22	VOR BIOPHARMA INC	COMMON STOCK	$96.4M	5404998	1.02%	SOLE
23	GERON CORP	COMMON STOCK	$95.0M	63771366	1.01%	SOLE
24	ARS PHARMACEUTICALS INC	COMMON STOCK	$87.2M	10860977	0.92%	SOLE
25	SAREPTA THERAPEUTICS INC	COMMON STOCK	$84.9M	3902596	0.90%	SOLE
26	SPYRE THERAPEUTICS INC	COMMON STOCK	$81.8M	1621620	0.87%	SOLE
27	EVOMMUNE INC	COMMON STOCK	$80.3M	3494638	0.85%	SOLE
28	SOLID BIOSCIENCES INC	COMMON STOCK	$67.2M	9339978	0.71%	SOLE
29	ARTIVA BIOTHERAPEUTICS INC	COMMON STOCK	$63.5M	9853302	0.67%	SOLE
30	DAMORA THERAPEUTICS INC	COMMON STOCK	$62.1M	2399310	0.66%	SOLE
31	XENCOR INC	COMMON STOCK	$59.1M	4897237	0.63%	SOLE
32	LB PHARMACEUTICALS INC	COMMON STOCK	$54.5M	2208604	0.58%	SOLE
33	JADE BIOSCIENCES INC	COMMON STOCK	$51.6M	3671083	0.55%	SOLE
34	ACUMEN PHARMACEUTICALS INC	COMMON STOCK	$49.5M	20992669	0.52%	SOLE
35	4D MOLECULAR THERAPEUTICS IN	COMMON STOCK	$47.0M	5049779	0.50%	SOLE
36	FULCRUM THERAPEUTICS INC	COMMON STOCK	$46.4M	6053960	0.49%	SOLE
37	CAPRICOR THERAPEUTICS INC	COMMON STOCK	$45.8M	1507844	0.49%	SOLE
38	CENTURY THERAPEUTICS INC	COMMON STOCK	$40.1M	17754430	0.43%	SOLE
39	OLEMA PHARMACEUTICALS INC	COMMON STOCK	$38.8M	2600000	0.41%	SOLE
40	LENZ THERAPEUTICS INC	COMMON STOCK	$38.2M	4178823	0.41%	SOLE
41	MONOPAR THERAPEUTICS INC	COMMON STOCK	$36.6M	667207	0.39%	SOLE
42	PEPGEN INC	COMMON STOCK	$35.5M	20064545	0.38%	SOLE
43	DESIGN THERAPEUTICS INC	COMMON STOCK	$31.6M	2972973	0.34%	SOLE
44	MIRUM PHARMACEUTICALS INC	COMMON STOCK	$29.4M	318554	0.31%	SOLE
45	BIOAGE LABS INC	COMMON STOCK	$28.9M	1650648	0.31%	SOLE
46	LEXEO THERAPEUTICS INC	COMMON STOCK	$28.7M	5000000	0.30%	SOLE
47	ASSEMBLY BIOSCIENCES INC	COMMON STOCK	$28.3M	1020410	0.30%	SOLE
48	REZOLUTE INC	COMMON STOCK	$28.0M	9180000	0.30%	SOLE
49	AKTIS ONCOLOGY INC	COMMON STOCK	$26.9M	1503084	0.28%	SOLE
50	ALX ONCOLOGY HOLDINGS INC	COMMON STOCK	$26.1M	13011849	0.28%	SOLE

1–50 of 85

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Values in USD (reported in $thousands on 13F). Source: SEC EDGAR.