New Leaf Venture Partners, L.L.C.

Est. AUM

$43.05B

13F long equity, this entity only

Positions

Period

Sep 2025 (Q3)

SEC EDGAR

Sep 2025 (Q3)

#	Issuer	Class	Value	Shares	% Portfolio	Discretion
1	EWTX	EDGEWISE THERAPEUTICS INC	$16.71B	1030161	38.82%	DFND
2	ARVN	ARVINAS INC	$13.51B	1585721	31.38%	DFND
3	CRNX	CRINETICS PHARMACEUTICALS INC	$5.87B	141000	13.64%	DFND
4	COGT	COGENT BIOSCIENCES INC.	$3.60B	250765	8.37%	DFND
5	RLYB	RALLYBIO CORPORATION	$1.65B	3301603	3.83%	DFND
6	ALEC	ALECTOR INC	$1.01B	339569	2.33%	DFND
7	PASG	PASSAGE BIO	$702.0M	87426	1.63%	DFND

Values in USD (reported in $thousands on 13F). Source: SEC EDGAR.