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| # | Issuer | Value | Shares | % Portfolio |
|---|---|---|---|---|
| 1 | STATE STR SPDR S&P 500 ETF TPUT | $130.1M | 200000 | 6.72% |
| 2 | APOGEE THERAPEUTICS INC | $108.2M | 1284926 | 5.59% |
| 3 | XENON PHARMACEUTICALS INC | $97.4M | 1675000 | 5.03% |
| 4 | ERASCA INC | $86.6M | 5350000 | 4.47% |
| 5 | INSMED INC | $78.5M | 480000 | 4.05% |
| 6 | ROIVANT SCIENCES LTD | $77.6M | 2800000 | 4.01% |
| 7 | SPYRE THERAPEUTICS INC | $64.5M | 1279134 | 3.33% |
| 8 | CENTESSA PHARMACEUTICALS PLC | $55.6M | 1400000 | 2.87% |
| 9 | PRAXIS PRECISION MEDICINES I | $54.8M | 170000 | 2.83% |
| 10 | ANAPTYSBIO INC | $52.1M | 940000 | 2.69% |
| 11 | ALKERMES PLC | $47.7M | 1350000 | 2.47% |
| 12 | CYTOKINETICS INC | $46.2M | 700483 | 2.38% |
| 13 | ABIVAX SA | $45.1M | 405000 | 2.33% |
| 14 | TEVA PHARMACEUTICAL INDS LTD | $42.2M | 1400000 | 2.18% |
| 15 | ARCELLX INC | $41.7M | 362764 | 2.15% |
| 16 | MODERNA INCCALL | $40.6M | 800000 | 2.10% |
| 17 | NUVALENT INC | $30.7M | 300000 | 1.59% |
| 18 | TERNS PHARMACEUTICALS INC | $29.7M | 562631 | 1.53% |
| 19 | DIANTHUS THERAPEUTICS INC | $29.4M | 350000 | 1.52% |
| 20 | LEXEO THERAPEUTICS INC | $29.0M | 5050211 | 1.50% |
| 21 | COGENT BIOSCIENCES INC | $28.9M | 750000 | 1.49% |
| 22 | MADRIGAL PHARMACEUTICALS INC | $28.8M | 55000 | 1.49% |
| 23 | SUTRO BIOPHARMA INC | $26.6M | 1069519 | 1.38% |
| 24 | FORTE BIOSCIENCES INC | $26.2M | 1011890 | 1.35% |
| 25 | ORUKA THERAPEUTICS INC | $24.5M | 499673 | 1.27% |
| 26 | TREVI THERAPEUTICS INC | $23.9M | 2000172 | 1.23% |
| 27 | OVID THERAPEUTICS INC | $23.6M | 10636318 | 1.22% |
| 28 | ENLIVEN THERAPEUTICS INC | $23.0M | 586904 | 1.19% |
| 29 | ASCENDIS PHARMA A/S | $21.7M | 95000 | 1.12% |
| 30 | MINERALYS THERAPEUTICS INC | $20.3M | 750000 | 1.05% |
| 31 | AVALO THERAPEUTICS INC | $20.0M | 1340840 | 1.03% |
| 32 | BRISTOL-MYERS SQUIBB COCALL | $18.2M | 300000 | 0.94% |
| 33 | PROTAGONIST THERAPEUTICS INC | $18.1M | 172125 | 0.94% |
| 34 | CELLDEX THERAPEUTICS INC NEW | $15.9M | 500000 | 0.82% |
| 35 | ZURA BIO LTD | $15.3M | 2564303 | 0.79% |
| 36 | NURIX THERAPEUTICS INC | $15.0M | 967620 | 0.77% |
| 37 | SAVARA INC | $13.7M | 2512153 | 0.71% |
| 38 | OMEROS CORP | $13.2M | 6525000 | 0.68% |
| 39 | PERSPECTIVE THERAPEUTICS INC | $13.2M | 3164582 | 0.68% |
| 40 | HELIX ACQUISITION CORP III | $12.7M | 1250000 | 0.66% |
| 41 | ARROWHEAD PHARMACEUTICALS IN | $12.5M | 200000 | 0.65% |
| 42 | DAMORA THERAPEUTICS INC | $11.7M | 450000 | 0.60% |
| 43 | EUPRAXIA PHARMACEUTICALS INC | $11.5M | 1589005 | 0.59% |
| 44 | ALTO NEUROSCIENCE INC | $11.2M | 500000 | 0.58% |
| 45 | BRIDGEBIO PHARMA INC | $11.1M | 150000 | 0.58% |
| 46 | CULLINAN THERAPEUTICS INC | $11.1M | 781260 | 0.57% |
| 47 | BELITE BIO INC | $10.4M | 65000 | 0.54% |
| 48 | WAVE LIFE SCIENCES LTD | $10.2M | 1401727 | 0.52% |
| 49 | VERA THERAPEUTICS INC | $10.1M | 250000 | 0.52% |
| 50 | TYRA BIOSCIENCES INC | $9.9M | 257512 | 0.51% |
Values in USD (reported in $thousands on 13F). Source: SEC EDGAR.