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| # | Issuer | Value | Shares | % Portfolio |
|---|---|---|---|---|
| 1 | PRAXIS PRECISION MEDICINES I | $32.47B | 100781 | 20.34% |
| 2 | PROTARA THERAPEUTICS INC | $14.77B | 2834652 | 9.25% |
| 3 | SUTRO BIOPHARMA INC | $12.76B | 512160 | 7.99% |
| 4 | EVOMMUNE INC | $10.26B | 446255 | 6.43% |
| 5 | MAPLIGHT THERAPEUTICS INC | $10.02B | 492893 | 6.28% |
| 6 | TENAX THERAPEUTICS INC | $9.33B | 583333 | 5.84% |
| 7 | ABIVAX SA | $8.57B | 77000 | 5.37% |
| 8 | HERON THERAPEUTICS INC | $7.00B | 8753290 | 4.39% |
| 9 | IMMIX BIOPHARMA INC | $6.74B | 740000 | 4.22% |
| 10 | ESPERION THERAPEUTICS INC NE | $4.71B | 1720000 | 2.95% |
| 11 | EDESA BIOTECH INC | $4.33B | 827500 | 2.71% |
| 12 | ANTERIS TECHNOLOGIES GLOBAL | $3.88B | 700000 | 2.43% |
| 13 | INSPIREMD INC | $3.42B | 2099652 | 2.14% |
| 14 | XENCOR INC | $3.02B | 250000 | 1.89% |
| 15 | AVALO THERAPEUTICS INC | $2.76B | 185122 | 1.73% |
| 16 | EUPRAXIA PHARMACEUTICALS INC | $2.55B | 352000 | 1.60% |
| 17 | CYTOMX THERAPEUTICS INC. | $2.54B | 540000 | 1.59% |
| 18 | VERRICA PHARMACEUTICALS INC | $2.49B | 471559 | 1.56% |
| 19 | REZOLUTE INC | $2.29B | 750000 | 1.43% |
| 20 | LYELL IMMUNOPHARMA INC | $2.05B | 102000 | 1.28% |
| 21 | PROFOUND MED CORP | $1.85B | 285710 | 1.16% |
| 22 | VIRIDIAN THERAPEUTICS INC | $1.78B | 91123 | 1.12% |
| 23 | ROCKET PHARMACEUTICALS INC | $1.05B | 294643 | 0.66% |
| 24 | KAZIA THERAPEUTICS LTD | $1.01B | 135315 | 0.63% |
| 25 | NASUS PHARMA LTD | $797.8M | 359390 | 0.50% |
| 26 | QUOIN PHARMACEUTICALS LTD | $560.0M | 84849 | 0.35% |
| 27 | ARROWHEAD PHARMACEUTICALS IN | $407.6M | 6500 | 0.26% |
| 28 | PROTAGONIST THERAPEUTICS INC | $390.0M | 3700 | 0.24% |
| 29 | OVID THERAPEUTICS INC | $355.2M | 160000 | 0.22% |
| 30 | MINERALYS THERAPEUTICS INC | $298.0M | 11000 | 0.19% |
| 31 | CONTEXT THERAPEUTICS INC | $262.0M | 100000 | 0.16% |
| 32 | NURIX THERAPEUTICS INC | $248.0M | 16000 | 0.16% |
| 33 | CORBUS PHARMACEUTICALS HLDGS | $244.1M | 26000 | 0.15% |
| 34 | SYNDAX PHARMACEUTICALS INC | $233.6M | 10000 | 0.15% |
| 35 | PRECISION BIOSCIENCES INC | $220.0M | 40000 | 0.14% |
| 36 | IMMUNOME INC | $218.7M | 10000 | 0.14% |
| 37 | JASPER THERAPEUTICS INC | $215.0M | 245328 | 0.13% |
| 38 | DESIGN THERAPEUTICS INC | $212.8M | 20000 | 0.13% |
| 39 | ARTIVA BIOTHERAPEUTICS INC | $161.0M | 25000 | 0.10% |
| 40 | NEUMORA THERAPEUTICS INC. | $156.0M | 80000 | 0.10% |
| 41 | REPLIMUNE GROUP INC | $153.0M | 20000 | 0.10% |
| 42 | LARIMAR THERAPEUTICS INC | $148.5M | 33000 | 0.09% |
| 43 | XILIO THERAPEUTICS INC | $120.1M | 14285 | 0.08% |
| 44 | KALARIS THERAPEUTICS INC | $103.9M | 18000 | 0.07% |
| 45 | PMV PHARMACEUTICALS INC | $90.5M | 73000 | 0.06% |
| 46 | MACROGENICS INC | $86.7M | 30000 | 0.05% |
| 47 | KARYOPHARM THERAPEUTICS INC | $83.5M | 15000 | 0.05% |
| 48 | PROQR THRAPEUTICS N V | $72.9M | 45000 | 0.05% |
| 49 | GOSSAMER BIO INC | $23.0M | 70000 | 0.01% |
Values in USD (reported in $thousands on 13F). Source: SEC EDGAR.