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| # | Issuer | Value | Shares | % Portfolio |
|---|---|---|---|---|
| 1 | SPDR SERIES TRUSTPUT | $1.28B | 10000000 | 20.86% |
| 2 | GUARDANT HEALTH INC | $308.4M | 3338241 | 5.04% |
| 3 | IMMUNOVANT INC | $286.3M | 11526971 | 4.68% |
| 4 | TARSUS PHARMACEUTICALS INC | $252.5M | 3600000 | 4.12% |
| 5 | VAXCYTE INC | $249.9M | 4300000 | 4.08% |
| 6 | STRUCTURE THERAPEUTICS INC | $206.3M | 4279848 | 3.37% |
| 7 | AXSOME THERAPEUTICS INC. | $185.9M | 1100000 | 3.04% |
| 8 | APELLIS PHARMACEUTICALS INC | $182.3M | 4532374 | 2.98% |
| 9 | OCULAR THERAPEUTIX INC | $166.7M | 19686282 | 2.72% |
| 10 | VERA THERAPEUTICS INC | $165.2M | 4106067 | 2.70% |
| 11 | ALUMIS INC | $149.2M | 6772595 | 2.44% |
| 12 | IONIS PHARMACEUTICALS INC | $146.4M | 1950000 | 2.39% |
| 13 | NUVALENT INC | $141.0M | 1376324 | 2.30% |
| 14 | ALKERMES PLC | $127.0M | 3590323 | 2.07% |
| 15 | CENTESSA PHARMACEUTICALS PLC | $125.4M | 3158041 | 2.05% |
| 16 | MOONLAKE IMMUNOTHERAPEUTICS | $119.5M | 6408863 | 1.95% |
| 17 | MAZE THERAPEUTICS INC | $103.8M | 3477562 | 1.70% |
| 18 | ORUKA THERAPEUTICS INC | $99.8M | 2034203 | 1.63% |
| 19 | NURIX THERAPEUTICS INC | $98.4M | 6345244 | 1.61% |
| 20 | GENMAB A/S | $98.3M | 3663250 | 1.61% |
| 21 | CYTOKINETICS INC | $90.6M | 1374320 | 1.48% |
| 22 | GRAIL INC | $89.0M | 1722797 | 1.45% |
| 23 | LB PHARMACEUTICALS INC | $82.7M | 3352804 | 1.35% |
| 24 | MBX BIOSCIENCES INC | $82.3M | 2757569 | 1.34% |
| 25 | BICARA THERAPEUTICS INC | $80.8M | 4062500 | 1.32% |
| 26 | COMPASS PATHWAYS PLC | $67.3M | 12161496 | 1.10% |
| 27 | BIOMARIN PHARMACEUTICAL INC | $65.0M | 1150000 | 1.06% |
| 28 | BRIDGEBIO PHARMA INC | $62.5M | 841445 | 1.02% |
| 29 | IMMUNOCORE HLDGS PLC | $58.2M | 1931884 | 0.95% |
| 30 | TANGO THERAPEUTICS INC | $57.5M | 2750000 | 0.94% |
| 31 | DEFINIUM THERAPEUTICS INC | $56.7M | 3000000 | 0.93% |
| 32 | TERNS PHARMACEUTICALS INC | $56.6M | 1073877 | 0.92% |
| 33 | GERON CORP | $47.3M | 31720278 | 0.77% |
| 34 | ANI PHARMACEUTICALS INC | $46.1M | 600000 | 0.75% |
| 35 | CORMEDIX INC | $42.6M | 6274076 | 0.70% |
| 36 | ATAIBECKLEY INC | $42.5M | 12000000 | 0.69% |
| 37 | CELLDEX THERAPEUTICS INC NEW | $40.7M | 1283979 | 0.67% |
| 38 | COGENT BIOSCIENCES INC | $38.5M | 1000000 | 0.63% |
| 39 | CORVUS PHARMACEUTICALS INC | $36.5M | 2491539 | 0.60% |
| 40 | DYNE THERAPEUTICS INC | $36.3M | 2000000 | 0.59% |
| 41 | SOLENO THERAPEUTICS INC | $36.1M | 1078710 | 0.59% |
| 42 | ACLARIS THERAPEUTICS INC | $35.0M | 9345000 | 0.57% |
| 43 | VERADERMICS INC | $31.6M | 500000 | 0.52% |
| 44 | VERASTEM INC | $30.4M | 5740850 | 0.50% |
| 45 | ENGENE HOLDINGS INC | $29.8M | 4377572 | 0.49% |
| 46 | VIRIDIAN THERAPEUTICS INC | $27.3M | 1393944 | 0.45% |
| 47 | X4 PHARMACEUTICALS INC | $26.2M | 6339535 | 0.43% |
| 48 | SOLID BIOSCIENCES INC | $25.7M | 3565062 | 0.42% |
| 49 | ENANTA PHARMACEUTICALS INC | $24.7M | 1956867 | 0.40% |
| 50 | APOGEE THERAPEUTICS INC | $24.0M | 285000 | 0.39% |
Values in USD (reported in $thousands on 13F). Source: SEC EDGAR.