UPB

$3.23+0.62%visit website

Upstream Bio, Inc.

Market Cap

$177M

Live price × SEC shares (Aug 4, 2026)

Sector

Health Care

Industry

Biotechnology

Beta (raw)

1.58

24mo monthly vs SPY

P/E (TTM)

N/M

TTM to Jun 2026 · negative earnings

P/S (TTM)

56.0

TTM to Jun 2026 · revenue

P/B

0.7

Mkt cap / shareholders' equity

EV/EBITDA (TTM)

—

EV / TTM EBITDA

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Financial Statements

USD thousands	Q3 FY2025 Sep 30, 2025	Q4 FY2025 Dec 31, 2025	Q1 FY2026 Mar 31, 2026	Q2 FY2026 Jun 30, 2026	TTM Jun 30, 2026
Revenue	683	668	1,034	773	3,158
Research & development	32,975	40,169	36,565	36,089	145,798
Total operating expenses	38,517	46,835	44,649	43,141	173,142
Operating income	(37,834)	(46,167)	(43,615)	(42,368)	(169,984)
Income tax	0.00	0.00	0.00	0.00	0.00
Net income	(33,748)	(42,459)	(40,591)	(39,702)	(156,500)
EPS (basic) ($)	(0.63)		(0.75)	(0.73)	(2.88)
EPS (diluted) ($)	(0.63)		(0.75)	(0.73)	(2.88)
Weighted avg. shares (basic)	53,931		54,332	54,568
Weighted avg. shares (diluted)	53,931		54,332	54,568

Source: SEC XBRL filings (10-K, 10-Q). Per-share data in dollars; shares in thousands. Latest: 10-Q filed Aug 11, 2026, period ended Jun 30, 2026. flagged for review— withheld, failed a consistency check restated or split-adjustedhover a value for its source

Showing the last 5 quarters. 8 more quarters, back to Sep 2023, with Tormere Pro.

Signals

purchases / sales, 90d

Short Volume

14%

W/W +8.1pp

Market & Alt Data

News

Factor Profile

Pro

Pro feature

Fama-French factor analysis is available on the Pro plan.

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Velocity Score

3.69x

Avg Daily Selling (90d)

55.9 sh/day

Baseline Daily Selling

41.0 sh/day

Unique Sellers (90d)

Sort by

Type

Trade Date	Filed	Owner	Role	Type	Shares	Price	Value	Owned After
2026-09-16	2026-09-17	Ambrose Allison	General Counsel	Sale	485	$5.49	$3K	15.6K	View
2026-09-16	2026-09-17	Sutherland Everett Rand	Director & Chief Executive Officer	Sale	2,095	$5.49	$12K	68.7K	View
2026-09-16	2026-09-17	Houghton Adam	Chief Business Officer	Sale	700	$5.49	$4K	22.9K	View
2026-09-16	2026-09-17	GRAY MICHAEL	CFO and COO	Sale	853	$5.49	$5K	27.9K	View
2026-09-16	2026-09-17	Deykin Aaron	Chief Medical Officer	Sale	895	$5.49	$5K	32.3K	View

1–5 of 15

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Recent News

Syndax Pharmaceuticals (SNDX) Reports Q3 Loss, Beats Revenue Estimates

Yahoo · 2026-11-02

Upstream Bio (UPB) Options Chain & Prices 2026 $UPB

MarketBeat · 2026-10-20

Upstream Bio Presents Results from the Phase 2 VALIANT Trial of Verekitug for the Treatment of Severe Asthma in Oral Presentation at ERS Congress 2026

Yahoo Finance · 2026-09-08

Upstream Bio (NasdaqGS:UPB) Stock Forecast & Analyst Predictions

Simply Wall St · 2026-09-08

$UPB stock is down 9% today. Here's what we see in our data.

Quiver Quantitative · 2026-09-03

Upstream Bio on Track to Begin Two Phase 3 Verekitug Trials in Q1 2027

Yahoo Finance · 2026-09-01

Upstream Bio Reports Second Quarter 2026 Financial Results and Highlights Continued Progress

Yahoo Finance · 2026-08-11

Upstream Bio, Inc. (UPB) Upgraded to Buy: What Does It Mean for the Stock?

Yahoo Finance · 2026-07-14

UPB Forecast — Price Target — Prediction for 2027

TradingView · 2026-06-26

Is Upstream Bio, Inc. (UPB) a Rising Biotech Opportunity After New Analyst Coverage?

Yahoo Finance · 2026-06-25

Is Upstream Bio, Inc. (UPB) the Best Low Priced Stocks to Get Rich in 2026?

Yahoo Finance · 2026-06-23

Upstream Bio Presents New Responder Analyses Demonstrating Clinically Meaningful Improvements in CRSwNP in Significant Majority of Participants Treated with Verekitug in the Phase 2 VIBRANT Trial at EAACI 2026

Yahoo Finance · 2026-06-14

Upstream Bio Presents New Data from Phase 2 VIBRANT Trial of Verekitug Demonstrating Improvement in Asthma Symptom Control in Participants with CRSwNP and Comorbid Asthma at the ATS 2026 International Conference

Yahoo Finance · 2026-05-18

Upstream Bio Reports First Quarter 2026 Financial Results and Recent Business Highlights

Yahoo Finance · 2026-05-13

Why Did UPB Stock Plunge 40% Today?

Stocktwits · 2026-02-11

Informational purposes only, not investment advice.

Date	Insider	Type	Shares	Value
2026-09-16	Ambrose Allison	S	485	$2,662.65
2026-09-16	Sutherland Everett Rand	S	2,095	$11,501.55
2026-09-16	Houghton Adam	S	700	$3,843
2026-09-16	GRAY MICHAEL	S	853	$4,682.97
2026-09-16	Deykin Aaron	S	895	$4,913.55

UPB

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Upstream Bio, Inc. (UPB)

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